Isolated elevated aspartate aminotransferase: a surprising outcome for clinicians.
نویسندگان
چکیده
In this report a case of macro-aspartate aminotransferase in a 34-year-old pregnant woman is presented. Awareness of the existence of a macroenzyme is important because of their ability to cause diagnostic confusion, which leads to unnecessary investigations. Confirmation with a polyethylene glycol precipitation test is simple to perform and not expensive.
منابع مشابه
Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient
Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported....
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BACKGROUND The presence of macroenzyme (M) is often the explanation of an isolated elevation of aspartate aminotransferase (AST). Where M is identified, it is reasonable for the clinician to ask where an individual patient's result fits in with known concentrations of M. In this context, we conducted a survey of literature to examine the distribution of reported serum concentrations of macro-AS...
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ورودعنوان ژورنال:
- The Netherlands journal of medicine
دوره 70 3 شماره
صفحات -
تاریخ انتشار 2012